By Gajja S. Salomons, Markus Wyss
This quantity locations emphasis at the problematic interaction among creatine and creatine kinase functionality on one hand and correct mind functionality, neurodegenerative ailment and/or neuroprotection at the different. The publication, compiled via striking specialists, offers a key reference summarizing the cutting-edge in creatine and creatine kinase examine. it's a must-read for knowing the hyperlinks among creatine metabolism and neuroprotection in addition to neurodegenerative sickness.
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Extra resources for Creatine and Creatine Kinase in Health and Disease (Subcellular Biochemistry, 46)
S. Salomons and M. ), Creatine and Creatine Kinase in Health and Disease, 27–65. © 2007 Springer. 28 1. Saks et al. GENERAL DESCRIPTION OF THE CREATINE KINASE SYSTEM IN MUSCLE CELLS High work requirements and the unique contractile function of the heart have made cardiac muscle the most intensively studied object in bioenergetics. Among other items, the role of the creatine kinase (CK) system has been thoroughly studied in cardiac cells during several decades in many laboratories. In this review, we summarize the data regarding the role of the CK system in heart, with the aim to emphasize the most important evidences of functioning of this system.
Due to the symmetrical nature of the MtCK octamer, MtCK mediates contacts between the inner and outer membrane through four C-terminal proteolipid complexes with the outer membrane and four with the inner membrane, one of them depicted by a circle in C. The membrane-bound state of octameric MtCK is strongly favored by the large membrane interaction surface and the high affinity of MtCK for cardiolipin (KD = 80 nM) and VDAC (KD < 100 nM). Binding of dimers to phospholipid membranes occurs with much lower affinity and probably involves association into octamers while bound to the membrane.
1990). , 2004). Sponges (phylum Porifera) are the most ancient, extant group of multi-cellular animals, having diverged from the metazoan lineage as much as a billion years ago (West and Powers, 1993). , 1957; Robin and Guillou, 1980) and more recent (Ellington, 2000) studies showed that these organisms contain Cr and CK activity. Sona et al. (2004) cloned and expressed in E. coli the cDNAs for three CKs from the sponge Tethya aurantia. One of these CKs, denoted CK2, corresponded to a true MtCK and contained a mitochondrial targeting sequence.