By Mark E Molitch
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Thomas Henry Huxley (1825-95) turned often called 'Darwin's bulldog' due to his forceful and vigorous aid for Darwin's conception, particularly on the infamous British organization assembly in Oxford in 1860. actually, Huxley had a few reservations approximately facets of the idea, in particular the component to slow, non-stop development, yet in public he used to be unwavering in his allegiance, announcing in a letter to Darwin 'As to your doctrines i'm ready to visit the Stake if requisite'.
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N Engl J Med 1993;329:683–689. 5. Crock PA. Cytosolic autoantigens in lymphocytic hypophysitis. J Clin Endocrinol Metab 1998;83:609– 618. 6. Feigenbaum SL, Martin MC, Wilson CB, Jaffe RB. Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy; proposal for medical treatment. Am J Obstet Gynecol 1991;164:1549–1555. CASE #3: PITUITARY APOPLEXY Case Presentation A 46-yr-old man presented to the emergency room of a community hospital with a 6-h history of a sudden, severe, frontal headache that awakened him from sleep.
The pattern of pituitary hormone losses (ACTH and prolactin) with sparing of the gonadotropins is also typical of hypophysitis. The presence of a family history of autoimmune diseases and the subsequent development of such a disease (Hashimoto’s thyroiditis) in our patient are consistent features of patients with adenohypophysitis (1–3). Lymphocytic hypophysitis is one of the recently appreciated entities that can cause a pituitary mass and hypopituitarism. It is an inflammatory process, likely to be autoimmune in nature that involves the pituitary gland.
Arafah BM, Ybarra J, Tarr RW, Madhun ZT, Selman WR. Pituitary tumor apoplexy: pathophysiology, clinical manifestations and management. J Intensive Care Med 1997;12:123–134. 2. Ebersold MJ, Laws ER Jr, Scheithauer BW, et al. Pituitary apoplexy treated by transsphenoidal surgery; a clinicopathological and immunocytochemical study. J Neurosurg 1983;58:315–320. 3. Reid RL, Quigley ME, Yen SSC. Pituitary apoplexy, a review. Arch Neurol 1985;42:712–719. 4. Arafah BM, Brodkey JS, Pearson OH. Gradual recovery of lactotroph responsiveness to dynamic stimulation following surgical removal of prolactinomas: long-term follow-up studies.