By Nancy N. Ragsdale, Robert E. Menzer
content material: Pesticide carcinogenicity / John Doull --
Pesticide legislation regarding carcinogenicity / James C. Lamb --
Pathogenesis of neoplasia and affects of insecticides / Gary M. Williams --
Mechanisms of chemical carcinogenicity / W.T. Stott ... [et al.] --
serious occasions and determinants in multistage pores and skin carcinogenesis / Thomas J. Slaga --
Pesticide-induced modulation of the immune procedure / Peter T. Thomas, Robert V. condo --
nutritional inhibition of melanoma / Diane F. Birt --
influence of chemical interactions at the improvement of melanoma --
Harihara M. Mehendale --
organic matters in extrapolation / Raymond S.H. Yang ... [et al.] --
Quantitative danger evaluate / C.J. Portier --
position of constitution / Yin-tak Woo, Joseph C. Arcos --
Sequential review of carcinogenic possibility and danger / John Ashby --
Epidemiological experiences of melanoma and pesticide publicity / Allan H. Smith, Michael N. Bates --
Pesticide residues and melanoma causation / Bruce N. Ames.
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Extra resources for Carcinogenicity and Pesticides. Principles, Issues, and Relationships
Even though A l i e t t e would r e p l a c e o t h e r much more c l e a r l y c a r c i n o g e n i c f u n g i c i d e s , however, the presence o f A l i e t t e on the p r o c e s s e d f o o d would have r e q u i r e d a f o o d a d d i t i v e (409) t o l e r a n c e . The Delaney c l a u s e i n S e c t i o n 409 p r e v e n t e d e s t a b l i s h i n g a 409 t o l e r a n c e , because A l i e t t e had been shown t o i n d u c e tumors i n a n i m a l s . T h i s s t r i c t d r a f t i n g and i n t e r p r e t a t i o n o f FFDCA S e c t i o n 409 p r e v e n t e d the use o f a b e n e f i c i a l and l e s s r i s k y p r o d u c t .
A few a c t i v a t i o n reactions, such as N-oxidation, acetylation, or n i t r o reduction can be performed by enzymes other than those of the cytochrome system. Most biotransformation takes place i n the l i v e r , with other organs involved to varying degrees (3). Certain b a c t e r i a l enzymatic actions, such as glucoside cleavge, n i t r o reduction, and azo reduction for certain tetrazo dyes, are involved i n the a c t i v a t i o n of compounds i n the i n t e s t i n e . For many epignetic carcinogens, such as hormones and organochlorine p e s t i c i d e s , metabolism leads to detoxified products.
The Delaney C l a u s e The Delaney c l a u s e can p r e v e n t the e s t a b l i s h m e n t o f t o l e r a n c e s and the r e g i s t r a t i o n o f p e s t i c i d e s . ; ACS Symposium Series; American Chemical Society: Washington, DC, 1989. LAMB Pesticide Regulation Related to Carcinogenicity (2) where i t has not (a "non-oncogenic" or u n t e s t e d p e s t i c i d e ) . I f one a l s o assumes t h a t the p e s t i c i d e s i n b o t h groups a l s o o t h e r w i s e pass the r i s k - b e n e f i t t e s t f o r FIFRA and FFDCA S e c t i o n 408, t h e n i t i s p o s s i b l e t o c o n s i d e r the i n f l u e n c e t h a t the Delaney c l a u s e has on p e s t i c i d e r e g i s t r a t i o n .