By Connie Henke Yarbro, Debra Wujcik, Barbara Holmes Gobel
A brand new and revised model of this best-selling reference! For over eighteen years, best-selling melanoma Nursing: rules and perform has supplied oncology nurses with the newest details on new tendencies within the swiftly altering technological know-how of oncology. Now, in its 7th variation, melanoma Nursing has been thoroughly revised and up to date to mirror key new advancements. New issues coated comprise distinctive remedy, hypersensitive reaction reactions, mucositis, and family members and caregiver concerns. With 27 new chapters that includes insights from key authors, the 7th version is a must have source for each oncology nurse.
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Extra resources for Cancer Nursing: Principles and Practice (7th Edition)
Martin, MSN, RN, AOCN (50, 62) Clinical Director Ambulatory Care Fox Chase Cancer Center Philadelphia, PA Kelley D. Mayden, MSN, FNP, AOCNP® (34) Oncology Nurse Practitioner Southwest Virginia Cancer Center Norton, VA Mary S. indd xl Karen Meneses, PhD, RN, FAAN (70) Professor and Associate Dean for Research School of Nursing University of Alabama at Birmingham Birmingham, AL Carrie J. Merkle, PhD, RN, FAAN (1) Associate Professor, Nursing College of Nursing University of Arizona Tucson, AZ Marcia Mickle, RN, MSN, ACNP, AOCN® (67) Nurse Practitioner, GI Oncology Northwestern Medical Faculty Foundation Chicago, IL Sandra A.
BRCA2 N372H DNA repair, etc. Breast CYP1A1 I462V Detoxification Lung (white nonsmokers) Abbrevations: CYP1A1, Cytochrome P450 1A1, XRCC1, Xray repair cross complementing protein1; 0GG1, 8-Oxoguanine DNA glycosylase; Source: Data from Hussain etal30 and Sun et al. 34 3/18/2010 1:04:45 AM CHAPTER 1 These complex signal transduction pathways control basic cell functions such as division, motility, and survival; consequently, they need to be highly regulated. Regulation often occurs through alterations in the enzymatic activity of key proteins in the pathways and assembly of large multimolecular signaling complexes within the cell.
Transformation is the process by which a normal cell becomes a cancer cell or develops some of the properties that are typical of cancer cells. One such property is loss of contact inhibition. When normal epithelial cells grow in culture, the cells often form a continuous single layer on a plastic surface, stopping at the boundaries of the chamber; at that point the population stabilizes and cell loss approximates cell growth. In contrast, tumor cells and some transformed cells will grow in multiple layers or clusters, reaching higher densities in culture, thus losing density-dependent 3/18/2010 1:04:44 AM CHAPTER 1 Biology of Cancer 5 TABLE 1-1 Key Points of Major Theories and Hypotheses of Tumorigenesis Theory or Hypothesis Key Points Theory of clonal expansion See text Multistep Tumorigenesis is a multistep process that includes initiation, promotion, and progression steps.