By Enzo Alessio
This ebook supplies a accomplished evaluate approximately medicinal inorganic chemistry. issues like concentrating on concepts, mechanism of motion, Pt-based antitumor medicinal drugs, radiopharmaceuticals are coated intimately and supply the reader an in-depth evaluate approximately this significant subject.
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The CXCR4 transmembrane receptor protein is widely expressed on cells of the immune, central nervous, and gastrointestinal systems, and also on many different types of cancer cells, besides playing a central role on the anchorage of CD34þ stem cells in bone marrow. Thus, cyclam derivatives may ﬁnd use in the treatment of various pathogenic disorders, including HIV infections, rheumatoid, allergic and malignant diseases, and in other diseases that can beneﬁt from stemcell mobilization. 11) has been shown to be a potent topical microbicide and has successfully completed phase II clinical trials for treatment of herpes simplex virus (HSV) .
Bacterial resistance to mercury antimicrobial agents involves induction of enzymes (such as mucuric reductase) that are capable of converting HgII in the cytoplasm into the less toxic and more volatile Hg . Antimony (SbV) compounds such as sodium stibogluconate (Pentostam) and meglumine antimonite (Glucantime) are used to treat leishmaniasis, a disease caused by a parasite that is transmitted by the bite of a certain species of sand ﬂy. The parasites replicate within mammalian macrophage phagolysosomes, initially causing skin sores, although some forms of the disease exhibit graver effects such as anemia and damage to the spleen and liver, which can be fatal.
As a consequence it can also interfere with calcium signaling, since Ca2þ is mobilized by inositol phosphates . 8 Anticancer Agents The discovery of the anticancer activity of cisplatin (cis-[PtII(NH3)2Cl2]) by Rosenberg and coworkers some 40 years ago and its subsequent approval for clinical use ten years later has done more for the advancement of inorganic medicinal chemistry than almost any other development in the ﬁeld. It is worth considering what has happened since and where platinum drugs are heading in the future (see also Chapters 3 and 4).