By James MacCabe; European Foundation for Psychiatry at the Maudsley
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Additional info for Beyond nature and nurture in psychiatry : genes, the environment, and their interplay
From a molecular genetic point of view GE correlation means that we ought to be able to find genes associated with environmental measures. In summary, quantitative genetic research does not find much evidence for GE interaction but it finds considerable evidence for GE correlation. We have skipped over this very quickly because we do not think that quantitative genetic results on GE interaction and correlation are very relevant for future research in this area, which will use specific genes as well as specific environments.
However, the best epidemiological evidence we have for humans in this context failed to corroborate these findings in animals. The Dutch famine study followed people who suffered famine while the Nazis laid siege to Holland during the Second World War. 12 It may be that the brain is spared during such dietary threat during pregnancy. Regarding other risk factors for low birth weight, smoking and alcohol consumption are biologically plausible factors that might modify the association between birth weight and cognition, since both interact with IGF.
A) shows a main effect of G, but no effect of E on the phenotype. (b) shows a main effect of E, but no effect of G. Very often, there is a main effect of both G and E, as illustrated in (c). (d) shows a main effect of both G and E, and a G × E interaction of the diathesis-stress type. GE correlation Although there is much interest these days in GE interaction, we predict that GE correlation will eventually be viewed as a more important topic. Although animal model research is powerful for investigating GE interaction because both genotype and environment can be manipulated experimentally, laboratory research has rarely considered GE correlation because it requires a menu of environments from which individuals can choose.