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Additional info for Batch fermentation : modeling, monitoring, and control
Exchange of energy between abiotic and biotic phases must be accounted for to determine the culture temperature. The temperature of the abiotic phase usually determines the temperature of the biotic phase. Some of the cellular reactions impact the acid-base equilibria in the biotic phase and in turn the pH of the abiotic phase, which in turn influences cellular activities and transport processes across the abiotic - biotic two-phase interface. In addition to transport of essential nutrients and end products of cellular metabolism between the two phases, one must also consider transport of ionic species (such as protons and cations).
The term "batch process" is often used to refer generically to both batch and fed-batch operations. In the former case, all ingredients used in the operation are fed to the processing vessel at the beginning of the operation and no addition or withdrawal of material takes place during the batch run. In the latter, material can be added during the batch run. For brevity, the term batch is used in this text to refer to both batch and fed-batch operations when there is no need to distinguish between them.
Chapters 2-5 focus on modeling. Chapter 6 presents a variety of process monitoring techniques. Chapter 7 presents control techniques for batch process operation and Chapter 8 discusses various fault diagnosis paradigms. Chapter 9 outlines recent developments that will impact fermentation process modeling, monitoring, Copyright © 2003 by Taylor & Francis Group, LLC Chapter 1. 4. Lr1 x 10) (*) and biomass (•) concentrations in a penicillin fermentation simulation . and control, and speculates about the future.