By Jens T. Carstensen
Delivering present facts on crystallization, dissolution from debris and polydisperse populations, powder volumes and densities, comminution, rainy granulation, and hard-shell pills, complicated Pharmaceutical Solids, describes moisture isotherms with crystalline solids, records the results of moisture on solid-state balance, highlights capsule physics and ideas, explains sustained free up by way of microencapsulation, offers prediction equations for solubility in binary solvents, discusses particle sizes and diameters, identifies Brunauer, Emmett, and Teller Isotherms and extra! contemplating houses of solids, permeamitry and fuel absorption tools, amorphates, and purification through pH-change precipitation, complicated Pharmaceutical Solids is an important reference for pharmacists pharmaceutical scientists medicinal, actual, floor, colloid, and analytical chemists and biochemists and an efficient textual content for upper-level undergraduate and graduate scholars in those disciplines.
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Extra info for Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical Sciences)
1985). ~ystemsof this type are often characterized by nonspecific van der ~ a a l forces s as well as strong specific interactions? so that the Hildebrand solubility parameters no longer can explain the instance, polar solutes in semipolar (or polar) solvents (Jouyba Acree, 1998). Drug substances maycomplexwithcomplexing agents. An exampleis ascorbic acid/niacinamide (niacinamide ascorbate). , drug A)? is called the substrate and the other ligand. A drug A (the substrate) will react with another compound I3 (the ligand) and form a weak e ~ u i l i b r i u ~ .
Lordi N, Sciarrone , Ambrosio T, Parta AN (1964). J Pharrn Sci 53:463. 6, A, Terol A, Masse J (1987). ~hermochimActa 121:283. alaviolle I, ~ e M a u r y Chauvet arshall AL (1931). In: Taylor, HS, ed. A Treatise on Physical Chemistry. Van Nostrand, New York, pp 336-338; 336-339. artin A, Newburger J, Adjei A (1980). J Pharm Sci 69:487. Martin A, Paruta A , Adjei A (1981). J Pharm Sci 70: 1115. Martin A, Wu PL, Liron Z, Cohen S (1985). J Pharm Sci 74:638. Pharm Sci 74: 132. School of Pharmacy, University of Wisconsin, A, Gray DB, Hussain MA (1996).
It will be seen later, that this is particularly true for a compoun~ that is, itself, an electrolyte). 10 shows the effect of sodium chloride concentration on the solubility of a bisnaphthalimide derivative. The use of mixedsolvent systems isoften necessary in pharmaceuti~swhen a drug is poorly soluble. Cosolvents used are Ethanol Propylene glycol Glycerin olyoxyethylene glycols Ternary diagrams are used to visualize wheremaximum solubility occurs when more than one solvent is used (Fig. 1 1).